Can we use suppositories?

Small intestinal (ileal) tissue is way more absorbent than rectal tissue, and for that reason I think we should be more cautious when using suppositories where a medication is absorbed into the blood stream (i.e. not lubricant suppositories).

But I also think this could be a good thing if managed or understood well, it would mean getting a stronger dose and faster than rectal absorption.

Thoughts and experiences?