Conservation and re-wilding projects on the east coast of the United States ?

It's not uncommon to hear about large rewilding projects in the western half of the United States such as the restoration of prairie and by extension the American Buffalo, Sonoran jaguar retsoration project, wolf reintroduction etc. Are similarly ambition projects going on in say the Appalachians, New England/Adkirondack backcountry, Ohio river valley?