Most memorable changes to media due to irl events?

This most often happens because of something happening with the actor that requires the plot of the ongoing media to change, or some tragedy happening that requires parts of upcoming media to be changed that were reminiscent of it.

An example of the tragedy is 9/11. After 9/11 a ton of media in mid production was changed if it had anything like terrorist attacks, plane hijackings, or mentions of the twin towers. Two pieces of media this happened to is lilo and stitch and metal gear solid.

For an example of needed changes due to stuff happening with an actor, in house md the fairly major character Kutner committed suicide with no build up because his actor Kal Penn were hired by the Obama administration.

I was wondering if there were any similar changes to media mid production due to events like this that others found memorable.