Anyone tried vonoprazan (Voquenza)? It just got approved in the USA, but is commonly available in Asia.

EDIT: Took for about 4 weeks and it helped me maybe 50-70% each night, but I don't think acid suppression is a great long term solution. I believe it was more effective when I started, and then I built a tolerance to it, and got more bloated over time. I track my mood daily and noticed my mood drop noticeably. It is still far more effective than PPI's for me, for which I noticed no difference. I plan to just use it before bed on days when I didn't abstain to a strict diet. I don't think there exists a cure for most of us right now.

I'm curious if this might help as I didn't see any difference with PPI's for LPR.

• entirely different mechanism of action
  • PCAB (potassium competitive acid blocker) https://en.wikipedia.org/wiki/Discovery_and_development_of_proton_pump_inhibitors#Potassium-competitive_acid_blocker
• less variability with CYP2C19 polymorphisms compared to PPI
  • https://www.reddit.com/r/GERD/comments/180nd1o/psa_read_this_if_ppis_do_not_seem_to_help_you/
  • https://www.reddit.com/r/GERD/comments/69jgef/cyp2c19_gene_ppis_are_less_effective_in_rapid/
• rapid onset of action compared to PPI
  • 30 minutes versus 1 day (see pubmed link below)
• longer half life compared to PPI
  • 6-9 hours versus 1 hour (see pubmed link below)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972603/

http://voqueznapro.com (product that is bringing vonoprazan to USA)