You can get rid of Curse Cards?!
Beginning of Act 3 I got the opportunity to pick the Rich event, and visited a shop nearby. I jokingly picked the curse thinking it wouldn't work...and I realized Curses aren't as much of a liability as I thought they'd be. The money allowed me to pick up a free heal from the Waffle which saved my run since I did some bad pathing in my greed for a second shop!