Been playing strategy/card games for longer than most of you have been alive
I am 1 billion percent certain they will never be able to balance this game. The only hope is if they remove half the items from it right now, never add another item, and highly tune the drop rates and percentage afflictions. All of which absolutely will not happen.
They have created a piece of software through which the interactions and variables make it literally impossible to balance properly. As they add more items and more heroes it just exacerbates the problem. Remind me in 3 years where this game is and reread this post.