Can we afford our dream home?

My wife and I (30y/o DINKS) are selling our current home and gaining about $140k in equity. We are hoping to get our dream home for $575k. The all-in Mortgage with 20% down at 6.25% would be $3,700 (mortgage, insurance, HOA, and property taxes). This includes a 3-point buy down. Our gross household income is about $150k/year and is expected to grow. Our net take home is about $7,500/month. Our only debt is student loan payments of $350/month. We live frugally and have about $30k in savings and over $100k in retirement accounts combined.

Will this dream home make us house poor? We’ve been used to a $2,000 mortgage for a few years now so I’m worried the big mortgage increase will add financial stress to our current state. We will be moving out of a high-cost of living area into a lower-cost living area.