Theory/discussion- Could the Gameboy set be made workable?

When they announced the upcoming Gameboy set, the first question my gf asked me was, "Will it actually be a working Gameboy? Because that would be impressive". I said, probably not, but if it is big enough to put a Pi in, I expect someone will at least try to see if it is possible as soon as it's released.

Has anyone started to think about this? Thoughts?