How to effectively reduce dose properly
Hey guys so I ran into a strassman quote but couldn’t find the original. It stated that beta blockers like pindalol could effectively reduce dmt dosage needed by 2 to 3 x the amount. I’ll post the quote in the post. I couldn’t find any supporting evidence really but learned it may be used in some types of pharmahuasca and lsd synthesis so maybe? I would think for it to officially do this it would need to upregulate the 5-ht1a or 2a like a Pam or something. I’m not looking for drug stacks though. I’m curious if a non psychoactive drug exists that directly influences the prefrontal or thalamocortical cortex’s receptors responsible for producing hallucinations. I’ve heard claims about amphetamines like mdma reducing it and alcohol making it unpredictable but would prefer something not addictive or psychoactive. Open to some substances though if they directly correlate. I’m not counting other tryptamines though as that somewhat defeats the purpose.
Hey guys so I ran into a strassman quote but couldn’t find the original. It stated that beta blockers like pindalol could effectively reduce dmt dosage needed by 2 to 3 x the amount. I’ll post the quote in the post. I couldn’t find any supporting evidence really but learned it may be used in some types of pharmahuasca and lsd synthesis so maybe? I would think for it to officially do this it would need to upregulate the 5-ht1a or 2a like a Pam or something. I’m not looking for drug stacks though. I’m curious if a non psychoactive drug exists that directly influences the prefrontal or thalamocortical cortex’s receptors responsible for producing hallucinations. I’ve heard claims about amphetamines like mdma reducing it and alcohol making it unpredictable but would prefer something not addictive or psychoactive. Open to some substances though if they directly correlate. I’m not counting other tryptamines though as that somewhat defeats the purpose.